The following are proposed topic areas for the NIH 2014-1 SBIR Contracts Solicitation.

** NATIONAL INSTITUTES OF HEALTH (NIH)

National Cancer Institute (NCI):

• Development of Novel Therapeutic Agents that Target Cancer Stem Cells;
• Reformulation of Failed Chemotherapeutic Drugs;
  
• Validation of 3D Human Tissue Culture Systems that Mimic the Tumor Microenvironment;
• Proteomic Analysis of Single Cells Isolated from Solid Tumors;
  
• Generation of Site-Specific Phospho-Threonine Protein Standards for use in Cancer Assays;
• Development of a Biosensor-Based Core Needle Tumor Biopsy Device;
• Development of Radiation Modulators for Use During Radiotherapy;
• Software Tools for the Development of Environmental Measures Related to Cancer Health Behaviors and Resources.

National Center For Advancing Translational Sciences (NCATS):

• Development of Biomarkers for Rare Diseases as Endpoints for Clinical Trial Measurements;
  
• Development of Neurocognitive Pediatric Tools for Measuring and Analyzing Clinical Study Endpoints in Rare Neurocognitive Disorders;
  
• Exploring the Potential of CRISPR/CAS Genome-editing Tools;
  
• Droplet Detection System.

• Passive MRI Cardiovascular Guidewire;
  
• MRI Myocardial Needle Injection Catheter;
  
• Transcatheter Pulmonary Artery Resist;
  
• Value of Information Models for Clinical Trial Assessment;
  
• Development of Molecular Imaging Agents and Methods to Detect High Risk Atherosclerotic Plaque;
  
• Tools for Educating Children About Clinical Research.

National Institute On Aging (NIA):

• Development of Calorie-restricted and Nutrient-balanced Medicinal Food Products for Mitigation of Age-related Diseases or Conditions.

• Development of a Database of Non-English Measures and Instruments for Use in Alcohol Research.

• Biomedical Methods To Quantify Adherence To Prevention Clinical Trial Study � Products and Strategies;
  
• Simple, Inexpensive Assay for Five Common HIV Resistance Mutations;
  
• Capreomycin:
  
• Formulation for Oral Delivery;
  
• Adjuvant Development.

• Web Resource System for Prescription Drug Providers, Researchers and Users:
• The Prescription Drug Abuse Policy System (PDAPS);
  
• Technological Tools to Facilitate Implementation of Evidence-Based Substance Abuse Prevention Interventions among the Military;
  
• Products to Prevent (Lethal) Drug-induced Respiratory Depression;
  
• Bundled Service for Designing Methodologically Rigorous Animal Studies;
  
• Affordable Care Act (ACA) Web Platform to Integrate Behavioral Health & Prevention with Primary Care.

Center For Global Health (GCH):

• Development of Novel Malaria Parasite Metabolite-based Non-invasive Diagnostic Biosensor.

• Developing Rapid Test for the Diagnosis of Sickle Cell Disease;
  
• Development of Rapid, Point-of-care Tests for Cytomegalovirus (CMV);
  
• Nutrition Support for Group Homes Serving Individuals with Intellectual Disabilities.

National Center For Chronic Disease Prevention And Health Promotion (NCCDPHP):

• Promoting Regular Physical Activity for Older Adults through "Wayfinding" Technology;
  
• Development of Pills or Tablets to Expedite Water Fluoridation;
  
• Application for Improving Embryo Transfer Practices at Fertility Clinics.

National Center For Emerging Zoonotic And Infectious Diseases (NCEZID):

• Distinguishing Infection, Colonization, and Recurrence in Patients with Clostridium difficile;
  
• Development of Reagents for Diagnosis of Fungal Infections in Formalin-fixed Paraffinized (FFPE) Tissue Blocks;
  
• Rapid Detection of Endemic Fungal Infections in the United States;
  
• Development of Anti-Japanese Encephalitis Virus Human Monoclonal Antibodies Using Humanized Rodent Models;
  
• Formulation of Nootkatone in Soaps and Lotions for Lyme Disease Prevention.

National Center For HIV/AIDs, Viral Hepatitis, STD, AND TB Prevention (NCHHSTP):

• Development of a Rapid Test for Detection Hepatitis C Core Antigen in Clinical Samples;
  
• Development of a Laboratory Test for Detection of Serum Biomarkers Associated with Hepatocellular Carcinoma;
  
• The Innovative Delivery of Confidential Medical Information;
  
• Development of a Mobile Application for Homeless Youth and Providers;
  
• Leveraging Technology to Prevent STIs Using High-Intensity Behavioral Counseling;
  
• Assessing the Feasibility of e-measure Adoption in an EHR Environment.

National Center For Immunization And Respiratory Diseases (NCIRD):

• Thermostable Dry Vaccine Formulation for Microneedle Administration;
  
• Development of Anti-diphtheria Antibodies for Use in Humans.

Office Of Public Health Preparedness And Response (OPHPR):

• "Plug and Play" Global Health Security Initiative (GHSI) Response Tool;
  
• Improved Rapid Antimicrobial Susceptibility Testing from Primary Specimens.